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This dual action is what separates it mechanistically from semaglutide

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In vivo anti-melanogenesis activity and in vitro skin permeability of niacinamide-loaded flexible liposomes (Bounsphere)

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Early Phase 2 data suggest substantial weight loss, though it is important to note that no direct head-to-head trials comparing retatrutide with tirzepatide or other agents have been conducted

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